WebApr 13, 2024 · View Atlanta obituaries on Legacy, the most timely and comprehensive collection of local obituaries for Atlanta, Georgia, updated regularly throughout the day … WebAuthor(s): Garrison, Jennifer Lynn Advisor(s): Taunton, Jack Abstract: Specific small molecule inhibitors can be used as molecular tools to dissect complex cellular processes and illuminate basic biological questions, such as protein secretion. A random screen for inhibitors of cell adhesion molecule expression led to the identification of HUN-7293, a …
Small molecule modulation of protein secretion - eScholarship
Websubstrate-selective cotransin analogue CT8, was more resistant than wild-type HER3 but only at low coibamide A (3 nM) concentrations; HER3 (G11L/S15L) expression was inhibited by higher concentrations of either natural ... CT8, the CT8-induced loss of HER3 was shown to dramatically suppress HER2-HER3 signaling in HER2-amplified BT474 breast ... WebSec61 lateral gate, an interaction that is stabilized by cotransin binding (MacKinnon et al., 2014). To test whether apratoxin has a similar stabilizing effect, we prepared ER … mjop california
Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein ...
WebMar 15, 2015 · Abstract. A new cyclic decadepsipeptide was isolated from Chaetosphaeria tulasneorum with potent bioactivity on mammalian and yeast cells. Chemogenomic profiling in S. cerevisiae indicated that the Sec61 translocon complex, the machinery for protein translocation and membrane insertion at the endoplasmic reticulum, is the target. WebHER3 (G11L/S15L), that is fully resistant to the highly substrate-selective cotransin analogue CT8, was more resistant than wild-type HER3 but only at low coibamide A (3 … Webmutations (this study) were treated with increasing concentrations of apratoxin (left) or CT8 (right) for 72 h, and viability was assessed by the Alamar Blue assay (mean ± S.D., n = 4). Desensitizing effect was calculated based on measured IC 50 values. (C) As in (B) except cotransin-resistant cells (MacKinnon et al 2014) tested with apratoxin. mjo prefix for anthem phone number