Crotonylome
WebQuantitative crotonylome analysis indicates that p300 regulates Kcr states of diverse cellular pathways. Moreover, bioinformatics analysis provides new insights into mechanisms of p300 functions. Together, this study illustrates a broad landscape of the Kcr pathway and therefore offers a rich source for studying the role of p300 in regulation ... WebSep 21, 2024 · 145 Quantitative lysine crotonylome analysis in different pluripotent states and 146 differentiated cells 147 We aimed to investigate protein crotonylation in mouse …
Crotonylome
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WebIn the current study, large-scale lysine crotonylome analysis was performed by a combination of affinity enrichment and high-resolution LC-MS/MS analysis. Altogether, 6051 lysine crotonylation sites were identified in 2508 protein groups. Bioinformatics analysis showed that lysine-crotonylated proteins were involved in many biological processes ... WebFeb 1, 2024 · Generation of a high-confidence crotonylome map in three pluripotent states and differentiating cells. A. Schematic view showing the culture of cells in four different cell states and the workflow for the crotonylome profiling. 2i represents ground state mouse ESCs cultured in serum-free medium with two inhibitors (MEK and GSK3) and LIF; S/L ...
WebPluripotent stem cells (PSCs) can be expanded in vitro in different culture conditions, resulting in a spectrum of cell states with distinct properties. Understanding how PSCs … WebAug 17, 2024 · In the current study, we verified that crotonylation was upregulated in hypoxia and promoted liver cancer cell growth. We performed TMT-labeled quantitative lysine …
WebMar 29, 2024 · To precisely determine hepatic Kcr changes caused by Acox2 knockout, global crotonylome analysis was performed using the liver tissues of Acox2 −/− (n = 3) … WebJun 29, 2024 · 100 (Phenomenex) and vacuum-dried. Peptide was reconstituted in 0.5 M TEAB and 101 processed according to the manufacturer’s protocol for TMT kit. Briefly, …
WebMay 6, 2024 · Results: Here, we performed the global analysis of crotonylome in tea leaves under NH 4 + deficiency/resupply using high-resolution LC-MS/MS coupled with highly …
WebOct 6, 2024 · Moreover, because of the lack of high-quality pan-antibodies, large-scale analysis of crotonylome still remains a challenge. In this work, we comprehensively … bbm kata adjektifbbm kata ganda penuhWebJan 11, 2024 · Crotonylome profiling of chrysanthemum has shown that the Kcr levels of 89 and 87 sites are increased and decreased, respectively, under low-temperature stress … dba salomon skoWebJun 22, 2024 · The most downregulated crotonylome alterations under p300 deficiency concern components of the nonsense-mediated decay, infectious disease, and viral/eukaryotic translation pathways. Moreover, some p300-targeted Kcr substrates are potentially linked to diseases such as cancer. Taken together, this study reveals the … dba sam\\u0027s grocery \\u0026 applianceWebFeb 1, 2024 · Generation of a high-confidence crotonylome map in three pluripotent states and differentiating cells. A. Schematic view showing the culture of cells in four different … bbm kemasanWebDec 16, 2024 · A comprehensive analysis of lysine crotonylome and protein modifications in paper mulberry seedlings was performed. In addition, extensive characterization of the crotonylome in paper mulberry indicates that crotonylation mainly occurred in proteins involved in multiple functions, ranging from control of metabolic processes to biological ... dba promet doo ariljeWebJul 14, 2024 · Later, crotonylome alterations by p300 were involved in nonsense-mediated decay, infectious disease, and viral/eukaryotic translation pathways . Additionally, 4.5% of the cancer protein biomarkers in the Early Detection Research Network database were crotonylated [ 25 ]. 5.9% of total genes in the Catalogue of Somatic Mutations in Cancer … dba ru1