Dithiolopyrrolones
WebDithiolopyrrolones exhibit relatively broad-spectrum antibiotic activity against many Gram-positive and Gram-negative bacteria, as well as strains of Mycobacterium tuberculosis. Additionally, they have been shown to exhibit potent and selective anti-cancer activity. WebOct 10, 2024 · Dithiolopyrrolones (DTPs), such as holomycin, are natural products that hold promise as scaffolds for antibiotics as they exhibit inhibitory activity against antibiotic-resistant pathogens. They consist of a unique bicyclic core containing a disulfide that is crucial for their biological activity. Herein, we establish the DTPs as prochelators.
Dithiolopyrrolones
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WebOct 10, 2024 · Dithiolopyrrolones (DTPs), such as holomycin, are natural products that hold promise as scaffolds for antibiotics as they exhibit inhibitory activity against …
WebMay 1, 2011 · Dithiolopyrrolones are known to be produced by several species of Streptomyces, Xenorhabdus and Alteromonas. The actinomycete S. algeriensis produces five dithiolopyrrolones in the basic medium (without precursors): thiolutin, iso-butyryl-pyrrothine, butanoyl-pyrrothine, senecioyl-pyrrothine and tigloyl-pyrrothine ( Lamari, … Web14. “Metals and mechanism of dithiolopyrrolones,” Metals in Biology Gordon Research Conference, Ventura, CA (Jan 27–Feb 1, 2024) 13. “Targeting metalloenzymes for antimicrobial therapy,” The 70th Southeastern Regional Meeting of American Chemical Society, Augusta, GA (Oct 31–Nov 3, 2024) 12.
WebRole for dithiolopyrrolones in disrupting bacterial metal homeostasis Andrew N. Chana, Anthony L. Shiverb, Walter J. Weverc, Sayyeda Zeenat A. Razvid, Matthew F. Traxlere, … WebJan 18, 2024 · DtpM catalyzes efficient conversion of holomycin to thiolutin, exhibits broad substrate scope toward dithiolopyrrolones, and has high thermal stability. In addition, sequence similarity network analysis …
WebProcédés innovants pour la production de dithiolopyrrolones par Saccharothrix algeriensis NRRLB-24137. 2024 • Alaa Hamdar. Download Free PDF View PDF. Bulletin de l'Académie Lorraine des Sciences, N°50, 2011. 2012 • Xavier …
WebApr 22, 2016 · N 4-methylation was supposed to be the last step in the biosynthetic process of thiolutin-type dithiolopyrrolones [25]. Although two SAM-dependent methyltransferase coding genes, orf2 and orf7, were found in the aut cluster, only unexpected desmethyl form of dithiolopyrrolones (holomycin-type) were detected in heterologous expression of the ... hot pursuit meaning in punjabiWebDithiolopyrrolones are a group of potent antibiotic natural products that have been found in both Gram-negative and Gram-positive bacteria. They consist of a unique pyrrolinonodithiole (4 H - [1,2] dithiolo [4,3- b] pyrrol-5-one) chromophore [ 4 ]. ho train amtrak passenger carWebMar 20, 2024 · However, the treatment with pure dithiolopyrrolones appeared less effective with about 50% of FOLi disease impact reduction, which thus suggested the … hotrega taugranulatWebDec 10, 2013 · Holomycin is an antibiotic with dithiolopyrrolone structure. The dithiolopyrrolones are formed by a two heterocyclic ring chromophore containing a … hot restarting adalahWebFeb 1, 2024 · The production of dithiolopyrrolones by Saccharothrix algeriensis was investigated after supplementing the culture medium with ethanol and/or 1-butanol. Optimal conditions for the addition of ethanol to the culture medium provided a maximal dithiolopyrrolone titer of about 200 mg⋅L −1 after 5 days of culture, roughly corresponding … felt z5 2010WebDithiolopyrrolones are microbial natural products containing a disulfide or thiosulfonate bridge embedded in a unique bicyclic structure. In the current study, two new dithiolopyrrolones, pyrroloformamide C (3) and pyrroloformamide D (4), were isolated from Streptomyces sp. CB02980, together with the known pyrroloformamides 1 and 2. The … felt z5WebOct 17, 2013 · Dithiolopyrrolones are a group of potent antibiotic natural products that have been found in both Gram-negative and Gram-positive bacteria. They consist of a unique pyrrolinonodithiole (4 H - [1,2] dithiolo [4,3- b] pyrrol-5-one) chromophore [ 4 ]. hotra peru