WebThe ephrin-B-EphB family plays a critical role in the maintenance of bone homeostasis. Ephrin-Eph signaling is bidirectional; thus, the binding between ligand and receptor triggers a signal transduction cascade downstream of both molecules (Fig. 3.10).The bidirectional nature of ephrin-Eph signaling is the basis of its role in coupling bone resorption to bone … WebEphrin‑A5, also known as AL‑1, RAGS, and LERK‑7, is an approximately 25 kDa member of the Ephrin‑A family of GPI‑anchored ligands that bind and induce the tyrosine …

Identification of an Enhancer Critical for the ephirn-A5 Gene ...

WebMay 16, 2016 · Ephrin-A5 induced EphB2-mediated growth cone collapse and neurite retraction in a model system. X-ray crystallography confirmed the interaction and showed that the ephrin-A5-EphB2 complex is a heterodimer. Himanen et al. (2004) emphasized the unexpected finding of crosstalk between A- and B-subclass Eph receptors and ephrins. Ephrin A5 is a protein that in humans is encoded by the EFNA5 gene. Ephrin A5 is a glycosylphosphatidylinositol (GPI)-anchored protein of the ephrin-A subclass of ephrin ligands that binds to the EphA subclass of Eph receptors. Ephrin A5 has also been shown to bind to the EphB2 receptor. See more "Reverse" signaling is one unique property of ephrin ligands that allows for the transmission of an intracellular signal in ephrin-expressing cells that is distinct from the signal transmitted in Eph receptor-expressing cells. … See more • Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. See more • Overview of all the structural information available in the PDB for UniProt: P52803 (Human Ephrin-A5) at the PDBe-KB. • Overview of all the structural information available in the See more metal roof exhaust vents

Cellular localization of ephrin-A2, ephrin-A5, and other functional ...

WebFeb 1, 1998 · Ephrin-A2 and -A5 RNA expression patterns differed across cell populations and between species, suggesting molecular mechanisms and key cellular interactions that may underlie fundamental differences in the development of retinotectal and retinocollicular maps. Publication types Comparative Study MeSH terms Animals Carrier Proteins / … WebEphrin-A5: Products. There are two structural groups of ephrin ligands which bind to a family of receptor tyrosine kinases (Eph). A-type ephrins bind A-type receptors, which … WebJan 21, 2016 · Further characterization of ephrin-A1–EphA2 and ephrin-A5–EphA2 crystals has shown that ephrin-A–EphA have functional interactions beyond their ligand-binding domains, which are likely to ... how ti test 2 year olds hearing