The ETS family is present throughout the body and is involved in a wide variety of functions including the regulation of cellular differentiation, cell cycle control, cell migration, cell proliferation, apoptosis (programmed cell death) and angiogenesis. Multiple ETS factors have been found to be associated with cancer, such as through gene fusion. For example, the ERG ETS transcription factor is fused to the EWS gene, resulting in a conditio… WebETS family transcription factors are among the end effector molecules of the signal transduction pathway. Phosphorylation of ETS modulates DNA binding, protein–protein …
The E-Twenty-Six Family in Hepatocellular Carcinoma: Moving …
WebNov 1, 2001 · A major mode of action of ETS-domain transcription factors is to recruit histone acetyl transferases or deacetylases to activate or repress transcription. ETS … WebThe ETS domain proteins are a diverse family of transcriptional activators that have been implicated recently in the expression of a number of cell-specific and viral promoters. Nuclear respiratory factor 2 (NRF-2) is a nuclear transcription factor that activates the proximal promoter of the rat cytochrome c oxidase subunit IV (RCO4) gene ... jesse glueck md
Regulation of EWSR1-FLI1 Function by Post-Transcriptional and …
WebApr 28, 2024 · With regard to energy metabolism, ETS1 regulates the transcription of the genes encoding enzymes involved in glycolysis (such as enolase 2 and aldolase C) and … October 2024 marked the 20th anniversary of Nature Reviews Cancer.This … WebJul 29, 2024 · Here we explore how a circuit of TFs coordinates pro-longevity transcriptional outcomes, which reveals a multi-tissue and multi-species role for an entire protein family: the E-twenty-six (ETS) TFs. In … WebApr 1, 2001 · The Ets family contains a growing number of transcriptional activators and inhibitors, which activity is regulated by phosphorylation and protein–protein interactions. Among these factors, Ets1, Erg1 and Fli1 are expressed in endothelial cells during angiogenesis in normal and pathological development. lampada g4 led 220v amarela