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Fstl1 monocyte

WebJun 2, 2024 · FSTL1 is a cardioprotective factor [ 4 ], pro-fibrotic agent [ 5 ], and a bi-directional regulator of tumor based upon the origin of the tumorigenic cell line [ 6 ]. Asthmatic patients express high levels of FSTL1 in plasma and bronchoalveolar lavage fluid (BALF) compared with health subjects [ 7 ]. WebOct 17, 2011 · The monocyte cell line U937, which does not express FSTL1, was transfected with a plasmid encoding FSTL1 and stimulated with phorbol myristate acetate and lipopolysaccharide. Cell supernatants were assayed for IL-6, IL-8, monocyte chemotactic protein 1 (MCP-1), and FSTL1 by enzyme-linked immunosorbent assay.

FSTL1 promotes liver fibrosis by reprogramming macrophage ... - PubMed

WebMar 24, 2024 · The FSTL1 protein was significantly less in lung tissues of Fstl1 +/− mice, and the increased FSTL1 protein after silica treatment was reduced in Fstl1 +/− mice (Fig. 2a). WebAug 5, 2024 · Follistatin-like 1 (FSTL1), a TGF-β-induced matricellular protein, is documented as an intrinsic regulator of proliferation and differentiation in MSCs. In the present study, we characterized the potential role of FSTL1 in MSC-based anti-fibrotic therapy and further elucidated the mechanisms underlying its action. Methods my ex asked me when will i have a boyfriend https://solrealest.com

Anti-FSTL1 Antibodies Invitrogen - Thermo Fisher Scientific

WebNov 15, 2024 · Follistatin-like 1 (FSTL1) has been widely reported as a proinflammatory mediator in different fibrosis-related and inflammatory diseases. Here we show FSTL1 expression to be closely correlated with activated fibroblasts and to be elevated in regenerative, fibrotic, and disease liver states in various mouse models. WebMar 21, 2024 · FSTL1 is a potential mediator of inflammation and insulin resistance in obesity. These results suggest that FSTL-1 may act on the NLRP3 inflammasome to … WebApr 11, 2011 · Follistatin-like 1 (Fstl1), first identified as a TGF-β1–inducible gene (), encodes a secreted extracellular glycoprotein belonging to the Fst-SPARC family, whose … offroadforen community

Endogenous Follistatin-like 1 guarantees the immunomodulatory ...

Category:Follistatin-related protein/follistatin-like 1 evokes an innate …

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Fstl1 monocyte

FSTL1 promotes liver fibrosis by reprogramming macrophage

WebMay 17, 2014 · Follistatin-like protein 1 (FSTL1), a secreted glycoprotein, also named TSC-36 [transforming growth factor (TGF)β 1-stimulated clone 36] or FRP (follistatin-related protein), was originally cloned from the mouse osteoblastic cell line MC3T3-E1 [].FSTL1 is widely expressed in human and mouse tissues, although its expression was found to be … WebFSTL1 and TREM1 were significantly increased in cells with miR-181b downregulation. (c) miR-181b bound to the 3′-UTR regions of FSTL1 and TREM1, and binding was interrupted in mutant FSTL1 and ...

Fstl1 monocyte

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WebDec 2, 2016 · Follistain-like protein 1 (FSTL1), has been recently demonstrated to be involved in the embryo development of nervous system and glioblastoma. However, the … WebDec 1, 2024 · FSTL1 silencing largely counteracts miR-579-3p knockdown-induced effects in M.tb-infected THP-1 macrophages. ... and further studies are needed to confirm these …

WebCardiovascular diseases [ edit] FSTL1 protein seems to have a cardioprotective role. FSTL1 attenuated hypertrophy following pressure overload [17] and prevented myocardial … WebJun 1, 2024 · 1. Introduction. Follistatin-like protein 1 (FSTL1) is a glycoprotein first discovered by Prof. Shibanuma from the transforming growth factor (TGF) β-stimulated …

WebWhile cells of mesenchymal lineage are capable of FSTL1 production, FSTL1 expression is notably absent from cells of hematopoietic lineage under normal physiological conditions. Macrophages and monocytes are, however, capable of taking up FSTL1 at sites of inflammation where FSTL1 stimulation can cause the expression of caspase-1 and its ... WebFeb 8, 2024 · Myeloid- specific FSTL1- knock out (FSTL1 M- OK) mice were constructed to explore the function and mechanism of macrophage FSTL1 in 3 murine models of liver fibrosis induced by carbon tetrachloride injection, bile duct ligation or a methionine-deficient and choline-deficient diet. Results FSTL1 expression was significantly elevated

WebJul 1, 2024 · Follistatin-like 1 (FSTL1) is a secreted glycoprotein displaying expression changes during development and disease, among which cardiovascular disease, cancer, and arthritis. The cardioprotective...

WebFSTL1, derived from fibroblasts/myofibroblasts in the interstitial compartment of the kidney can signal to kidney tubule cells in a paracrine manner, and contribute directly to the three cardinal processes that contribute to the progression of CKD: fibrosis, inflammation, and … off road ford f150WebSep 1, 2016 · Conversely, knockdown of FSTL1 significantly reduces the production of IL-6 and monocyte chemotactic protein 1 (MCP-1) induced by TNF-α and IL-17 [24]. Thus, these studies demonstrate that FSTL1 is a pro-inflammatory mediator that might be a target in treating inflammatory diseases, specifically rheumatoid arthritis. offroad ford explorer black and beigeWebOct 14, 2013 · We found that FSTL1 plays a dual role in bone metastasis—in one way by mediating tumor cell invasion and bone tropism but also in a second way by expanding a population of pluripotent mesenchymal stem-like CD45 … offroadforen.deWebFSTL1 reduces transcellular transport of LDL-sized particles and of LDL itself, and inhibits endothelial activation. ... (NF-κB), adhesion molecule expression and monocyte … off road ford ranger buildWebFeb 8, 2024 · demonstrated by attenuated infiltration of monocytes/ macrophages and neutrophils and decreased expression of proinflammatory factors. FSTL1M- OK macrophages ... FSTL1 plays a proinflammatory role is still debated.17–21 FSTL1 is widely regarded as a fibrosis-promoting protein both outside off road fordsWebMar 29, 2024 · Follistatin-like 1 (FSTL1) is a secreted glycoprotein displaying expression changes during development and disease, among which cardiovascular disease, cancer, … offroad ford explorerWebJan 2, 2024 · FSTL1 CD14 TLR4 Innate immunity Rheumatoid arthritis abstract Follistatin-related protein (FRP)/follistatin-like 1 (FSTL1) has multi-specific binding nature espe … off road ford flex