site stats

Ints13 function

WebIn the second chapter, I show that INTS13 functions as an independent submodule of Integrator and regulates enhancer activation in monocyte-macrophage differentiation. I reveal that INTS13 associates with NAB2 and the transcription factor EGR1 to activate poised enhancers, eliciting chromatin looping and gene activation. WebEnhancers are cis-regulatory books in the human that cooperative with promoters to control target genetische transfer. Unlike promoters, enhancers have not requires adjacent to destination genes and can exert their actions regardless of enhancer orientations, positions and spatial segregations from target genes. Thus, for a long choose, to question as to …

Targeted Enhancer Activation by a Subunit of the Integrator …

WebJul 9, 2024 · Here, we show that INTS10, Asunder/INTS13 and INTS14 form a separable, functional Integrator module. The structure of INTS13-INTS14 reveals a strongly entwined complex with a unique chain interlink. Unexpected structural homology to the Ku70-Ku80 DNA repair complex suggests nucleic acid affinity. WebJun 1, 2024 · Similarly, INTS13 represents an independent submodule targeted to poised enhancers [52]. Understanding the structural modularity and assembly of the complex, as well as its interaction with RNAPII (Box 1) will further enhance our understanding of Integrator functions and allow identification of potential interfaces for therapeutic … loomis after ship https://solrealest.com

INT 13 - Diskette BIOS Services - stanislavs.org

WebJul 5, 2024 · Integrator is a general activator of transcription at coding genes and is required for eRNA maturation. Here, we show that INTS13 functions as an independent sub-module and targets enhancers through Early Growth Response (EGR1/2) TFs and their co-factor NAB2. INTS13 binds poised monocytic enhancers eliciting chromatin looping and … WebINTS13. The antibodies are designated mAB for monoclonal and pAb for polyclonal. The release of the Human Protein Atlas in which the antibody was first published. All assays through which the antibody has been validated. Assays&annotation provide a detailed description of the different assays. loomis advocacy solutions

INTS13 Mutations Causing a Developmental Ciliopathy Disrupt

Category:Reference Query Results CTD

Tags:Ints13 function

Ints13 function

INTS10–INTS13–INTS14 form a functional module of ... - Nature

WebJul 24, 2007 · Function. function. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs ... INTS13 Q9NVM9: 16: EBI-4409724, EBI-741429: Expand table. Protein-protein interaction databases. BioGRID. 123520 101 interactors; ComplexPortal. CPX-6441 Integrator complex; WebHere, we review the structural and functional data on the DNA and RNA recognition properties of Ku implicated in DNA repair and in telomeres maintenance. Next Article in Journal. Transgenerational Effects of Di(2-Ethylhexyl) Phthalate on Anogenital Distance, ... (INTS13/INTS14), with a structure reminiscent of the Ku heterodimer, was recently ...

Ints13 function

Did you know?

WebJul 9, 2024 · Here, we show that INTS10, Asunder/INTS13 and INTS14 form a separable, functional Integrator module. The structure of INTS13-INTS14 reveals a strongly entwined complex with a unique chain interlink. WebBergfort A, Preußner M, Kuropka B, Ilik İA, Hilal T, Weber G, Freund C, Aktaş T, Heyd F, Wahl MC.

WebNX_Q9NVM9 - INTS13 - Integrator complex subunit 13 - Function. Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component … WebSep 1, 2024 · In addition, Barbieri and colleagues showed that INTS13 functions as an independent submodule to mediate activation of monocytic enhancers through EGR1 and NAB2. Other INT subunits, including INTS11, INTS1, and …

Webfunction. Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. ... INTS13 Imported. Synonyms. ASUN Imported, C12orf11, GCT1. Organism names. Organism. Homo sapiens (Human) Taxonomic identifier. 9606 NCBI. WebINTS13 (ASUN, C12orf11, FLJ10637, Mat89Bb, NET48, SPATA30) Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl. A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the Tissue ...

WebLegend. Settings. Analysis

WebDetect, measure, and explore your target protein's identity and function using our products: peptides, recombinant proteins, antibodies, ELISA kits, NGS, and more. All Cell Cycle Antibodies Research Areas - ABclonal loomis advertising agencyWebThe authors show that the INTS10-inTS13-INTS14 complex forms a distinct submodule of INT and suggest it facilitates RNA substrate targeting and suggests that it brings cleavage module and target transcripts into proximity. The Integrator complex processes 3′-ends of spliceosomal small nuclear RNAs (snRNAs). Furthermore, it regulates transcription of … loomis agency logoWeb(Click on the icon in the table below to see search hit context) horaires botanic mulhouseWebJun 28, 2024 · Europe PMC is an archive of life sciences journal literature. horaires bercy montargisWebCROSS-REFERENCE TO RELATED APPLICATIONS. This application is a Continuation of U.S. patent application Ser. No. 16/649,732, filed Mar. 23, 2024, which is a national stage filing u loomis ace hardware hoursWebINTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module Nature Communications 9. Juli 2024 ... Our review "Ribosome biogenesis factors-from names to functions" has been published in EMBO Journal. It was a pleasure working together on this ... loomis air freightWebGene target information for Ints13 - integrator complex subunit 13 (house mouse). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. loomis a fit notes