WebIn the second chapter, I show that INTS13 functions as an independent submodule of Integrator and regulates enhancer activation in monocyte-macrophage differentiation. I reveal that INTS13 associates with NAB2 and the transcription factor EGR1 to activate poised enhancers, eliciting chromatin looping and gene activation. WebEnhancers are cis-regulatory books in the human that cooperative with promoters to control target genetische transfer. Unlike promoters, enhancers have not requires adjacent to destination genes and can exert their actions regardless of enhancer orientations, positions and spatial segregations from target genes. Thus, for a long choose, to question as to …
Targeted Enhancer Activation by a Subunit of the Integrator …
WebJul 9, 2024 · Here, we show that INTS10, Asunder/INTS13 and INTS14 form a separable, functional Integrator module. The structure of INTS13-INTS14 reveals a strongly entwined complex with a unique chain interlink. Unexpected structural homology to the Ku70-Ku80 DNA repair complex suggests nucleic acid affinity. WebJun 1, 2024 · Similarly, INTS13 represents an independent submodule targeted to poised enhancers [52]. Understanding the structural modularity and assembly of the complex, as well as its interaction with RNAPII (Box 1) will further enhance our understanding of Integrator functions and allow identification of potential interfaces for therapeutic … loomis after ship
INT 13 - Diskette BIOS Services - stanislavs.org
WebJul 5, 2024 · Integrator is a general activator of transcription at coding genes and is required for eRNA maturation. Here, we show that INTS13 functions as an independent sub-module and targets enhancers through Early Growth Response (EGR1/2) TFs and their co-factor NAB2. INTS13 binds poised monocytic enhancers eliciting chromatin looping and … WebINTS13. The antibodies are designated mAB for monoclonal and pAb for polyclonal. The release of the Human Protein Atlas in which the antibody was first published. All assays through which the antibody has been validated. Assays&annotation provide a detailed description of the different assays. loomis advocacy solutions