2024 Jph2 molecular weight

Jph2 molecular weight

Author: klij

August undefined, 2024

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic membrane occupa… NettetView Mouse Monoclonal anti-JPH2 Antibody (OTI1F5) (NBP2-45469). Validated Applications: WB, ICC/IF. Validated Species: Human, Mouse, Rat. Skip to main content ... The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, …

Emerging role of junctophilin-2 as a regulator of calcium handling …

NettetUseful information about the protein provided by UniProt. [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcopl asmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes 1. Provides a structural foundation for functional cross-talk between the ... Nettet18. apr. 2007 · Junctophilin-2 (JPH2) is a cardiac specific member of the junctophilins, a newly characterized family of junctional membrane complex proteins important in physically approximating the plasmalemmal L-type calcium channel and the sarcoplasmic reticulum ryanodine receptor for calcium-induced calcium release. titanic shipwreck 3d

Nanoscale coupling of junctophilin-2 and ryanodine receptors

Nettet18. okt. 2024 · Junctophilin 2, as junctional membrane complex (JMC) protein, is an important regulator of the cardiac SK channels RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure loss of nuclear JP2NT function accelerates stress-induced development of hypertrophy and heart failure in mutant mice Nettet1. sep. 2024 · Matsushita et al. (2007) noted that the JPH2 protein is composed of 6 predicted domains: MORN (membrane occupation and recognition nexus) motif region I … Nettet9. aug. 2010 · Junctophilin-2 (JPH2) is a membrane-binding protein that plays a key role in the organization of the junctional membrane complex (JMC) in cardiac myocytes. JPH2 is believed to keep the plasma ... titanic ships for sale

Heterozygous junctophilin-2 ( JPH2 ) p.(Thr161Lys) is a

Jph2 molecular weight

Positive dose-dependent relationship between JPH2 expression …

NettetThe standard atomic weight takes into account the isotopic distribution of the element in a given sample (usually assumed to be "normal"). For example, water has a relative molecular mass of 18.0153 (3), but individual water molecules have molecular masses which range between 18.010 564 6863 (15) Da ( 1 H 216 O) and 22.027 7364 (9) Da ( … Nettet17. jan. 2003 · HGNC:14202 JPH2 MIM 605267 gene 613873 phenotype 619492 phenotype VEuPathDB HostDB:ENSG00000149596 neXtProt NX_Q9BR39 Subcellular …

Did you know?

NettetJPH2 is a hot spot for mutations linked to hypertrophic cardiomyopathy (HCM) ( 15 – 17 ), and repeats in JPH3 have been found to cause Huntington disease-like 2 (HDL-2) ( 18 ). In addition, cardiac stress results in activation of calpain, which cleaves JPH2 and drives heart failure progression ( 19 – 24 ). NettetKnow comprehensive JPH2 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

NettetConstruction of a sulfonation modification system for preparation of heparins having different molecular weights, and an application thereof, relating to the technical field of bioengineering. By means of synthetic biological technology and genetic engineering means, and by using Pichia pastoris GS115 as a starting strain, heparin synthesis … Nettet24. jan. 2006 · Junctophilin-2. Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for …

NettetThe molecular weight distribution (MWD) is conveniently characterized by either the number N(n) or weight W(n) of chains with n repeating units (e.g., a chain with molecular weight M = nm0 with m0 the molar weight of a repeating unit). The normalized functions N — (n) = N(n)/ΣN(n) (1) N — (n) = W(n)/ΣW(n) (2) respectively, are the number ... NettetTwelve 8-week-old male SD rats with a mean weight of 273.7 ± 3.2 g were randomized into two groups: six rats were subjected to saline (Double Crane Pharmaceutical Co. …

Nettet15. jun. 2014 · Mice with cardiac-specific shRNA-mediated knockdown of JPH2 were unable to form mature T-tubules within the first few weeks of life, while Bin1 levels remained unchanged. 14, 16 Conversely, T-tubule maturation occurred earlier in mice overexpressing JPH2 (Figure 1). 14 The disruption in maturation preferentially affected …

Nettet30. mar. 2024 · ( G) mRNA expression levels for JPH2 and CAV3. ( H) Protein expression levels determined using JPH2 (sc-51313, Santa Cruz Biotechnology) and CAV3 (ab2912, Abcam) antibodies. n = 5 per group for G and H. * P < 0.05 and ** P < 0.01 vs. the euthermic group by Student’s t test. Open in viewer Increased Expression of JPH2 and … titanic shipwreck exploration скачатьNettet28. aug. 2024 · The number average molecular weight (M n) is given by 2.2.7 , where M i is molecular weight of a molecule of oligomer n, and N i is number of molecules of that molecular weight. Total weight = Σ ∞ i = 1MiNi. Total number = Σ ∞ i = 1Ni. Mn = Σ ∞ i = 1MiNi Σ ∞ i = 1Ni. Example 2.2.8. titanic shipwreck google mapsNettetGene Symbols: JPH2 Molecular weight: 74,222 Da Basal Isoelectric point: 8.82 Predict pI for various phosphorylation states titanic shipwreck coordinatesNettet9. aug. 2010 · Junctophilin-2 (JPH2) is a membrane-binding protein that plays a key role in the organization of the junctional membrane complex (JMC) in cardiac myocytes. titanic shipwreck artifactsNettet1. sep. 2024 · HGNC Approved Gene Symbol: JPH2 Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,106,590-44,187,188 (from NCBI) Gene-Phenotype Relationships PheneGene Graphics TEXT Description titanic shipwreck facts titanic shipwreck drawingNettet7. okt. 2024 · Protein lysates from whole cerebral arteries and hearts probed with a primary antibody against JPH2 produced bands at the predicted molecular weight of the protein … titanic shipwreck pictures