Paclitaxel resistant cell line
WebWe conducted a phase II trial to evaluate the safety and efficacy of weekly paclitaxel in patients with resistant or relapsed non-small cell lung cancer (NSCLC) treated with docetaxel and carboplatin. Thirty-two NSCLC patients at a median age of 58.0 years (range 33-75) were enrolled. The Eastern Co … WebNov 26, 2024 · Paclitaxel is one of the first-line chemotherapeutic agents for recurrent or metastatic cervical cancer 16. CSCs resistance to paclitaxel has been reported. For instance, ovarian CSCs were...
Paclitaxel resistant cell line
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WebAug 4, 2024 · Paclitaxel-resistant cells were established from parental lines by incubating cells in paclitaxel-containing growth media using recurrent 48-hour treatment cycles until a stable pool of resistant clones was confirmed. WebThe CA12 gene silencing was dramatically promoted the sensitivity of paclitaxel in paclitaxel-resistant cell line MCF-7 TaxR. The CA12 silencing in MCF7 TaxR cells …
WebSep 24, 2024 · The SKOV3/MRP7 cell line was resistant to multiple anticancer drugs including paclitaxel, docetaxel, vincristine and vinorelbine with a maximum of 8-fold resistance. Biological function of MRP7 protein was further determined by efflux-accumulation assays. WebEpithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related death. The high mortality and morbidity associated with EOC are mostly due to late diagnosis …
WebPaclitaxel, which is a substrate of P-glycoprotein, is the first-line drug for breast cancer chemotherapy [ 13 ]. However, many breast cancer patients have developed chemotherapy failure because of the occurrence of paclitaxel (PTX) resistant cells. Currently, no drugs specifically targeting PTX-resistant breast cancer are available. WebMay 19, 2024 · The nab-paclitaxel-resistant cell lines MiaPaCa-2/NPR and Panc-1/NPR were selected for at least 100 days, as described in the methods section. The resistant …
WebOct 21, 2024 · In the majority of established chemoresistant cell lines, Cisplatin is the drug mostly used for the induction of resistance ( 26 ). PTX-resistance induction is less …
WebThe paclitaxel (PTX) resistant A2780 PTX (4) cell line with collateral sensitivity to cisplatin (CDDP) (inverse resistance) has been developed by continuous growing of A2780 … straight wide leg black jeansWebJun 18, 2024 · Paclitaxel (PTX), the most widely used taxane, has become the first-line drug against OC. The molecular mechanism of PTX resistance is different from that of platinum-based agents and is... rotman finance labWebJan 13, 2024 · Background: Drug resistance is a major obstacle in chemotherapy for ovarian cancer, wherein the up regulation of drug-resistant genes plays an important … straight window well coversWebOct 21, 2024 · Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein … rotman financeWebA hub protein was defined as one having a degree cutoff of ≥1 and was simultaneously differentially expressed between parental cell lines and paclitaxel-resistant cell lines. Among 79 nodes, we determined 28 hub genes (Fig. (Fig.2, 2 , Supplementary Table 3 , 4) and further predicted their signaling pathways and validated their clinical ... rotman finhubWebMethods: Using the dose calculated from clinical chemotherapy, we established a TAX-resistant human ovarian carcinoma cell line OC3/TAX300 by intermissive and repeated … rotman finance associationWebJun 12, 2024 · On ABCB1 over-expressing and Dox resistant human breast cancer MCF-7/dox cells, Quercetin significantly enhances the antitumor activity of Dox, paclitaxel, and vincristine. The combined treatment of Dox, paclitaxel, and vincristine with Quercetin significantly down-regulates ABCB1 expression and eliminates breast cancer stem cells … straight wine glasses