Prodrug related articles
WebbActivation of cyclooxygenase (COX)/prostaglandin and nuclear factor κB (NFκB) pathways can promote breast tumor initiation, growth, and progression to drug resistance and metastasis. Thus, anti-inflammatory drugs have been widely explored as … WebbA prodrug is a conjugate of a known drug and a promoiety. In general, a prodrug is an inactive form of the drug; however, its chemistry helps to overcome certain inherent …
Prodrug related articles
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Webb5 apr. 2024 · Reviewed by Emily Henderson, B.Sc. Apr 5 2024. Chemotherapy treatments produce strong side effects. A new agent that accumulates in the tumor tissue and is activated there by ultrasound waves does ... Webb28 juni 2008 · Mono amino acid ester prodrugs of antiviral and anticancer drugs such as gemcitabine, acyclovir, and 2-bromo-5,6-dichloro-1- ( β -D-ribofuranosyl)benzimidazole (BDCRB) have been synthesized and evaluated for their suitability as transporter substrates in our previous reports [ 15, 24, 40, 41, 42, 43 ].
WebbProdrugs are inactive precursors of an active drug designed to be bioconverted (activated) post administration with the main aim of improving the pharmacokinetic properties of … WebbThe prodrug concept is a potential way to deliver those drug molecules that have low ocular BA due to several physicochemical and physiological limitations. The designing of …
WebbBrain-targeting prodrugs [26] are extensions of simple prodrugs in terms of having a specific pro-moiety whose major function is to promote access and retention in the brain. This may be achieved by in situ metabolic conversion of a non-ionic pro-moiety (e.g., 1,4-dihydropyridine) to an ionic (e.g. Webb12 nov. 2003 · The objective of this work was to design an acyclovir prodrug that would utilize the human apical sodium-dependent bile acid transporter (hASBT) and enhance acyclovir oral bioavailability. Using each chenodeoxycholate, deoxycholate, cholate, and ursodeoxycholate, four bile acid prodrugs of acyclovir were synthesized, where acyclovir …
Webb13 aug. 2015 · Accordingly, the prodrug compounds can have a structure of Formula I, analogs thereof, derivatives thereof, or salts thereof, wherein: A and B are sulfur or oxygen; R1 and R2, in para, meta, or ortho position, are independently halogen, alkyl, alkoxy, haloalkyl, where R1 and R2 independently are straight chain, branched, substituted or …
WebbThe background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and … growth employment and redistributionWebb15 sep. 2024 · The term “prodrug” is also meant to include any covalently bonded carriers, which release the active compound in vivo when such prodrug is administered to a subject. Prodrugs of a compound may be prepared by modifying functional groups present in the compound in such a way that the modifications are cleaved, either in routine … grow themeWebb18 juni 2024 · Globally, chronic hepatitis B (CHB) infection is one of the leading causes of liver failure, decompensated cirrhosis, and hepatocellular carcinoma. Existing antiviral therapy can suppress viral replication but not fully eradicate the virus nor the risk of liver-related complications. Novel treatments targeting alternative steps of the viral cycle or … filter in originWebbFer-Me was hydrolyzed to Fer in rat whole blood and liver homogenate, evidencing its prodrug behavior. Furthermore, Fer-Me displayed antioxidant and anti-inflammatory properties. The amount of encapsulated Fer-Me was 0.719 ± 0.005% or 1.507 ± 0.014% in tristearin or stearic acid SLMs, respectively. filter in onenoteWebb11 apr. 2024 · Prodrugs-Passive-Chemical. Good drug stability: Size increase reduces transdermal permeability: Ita : Thermal ... classified in three generations: First, second and third. First-generation systems developed till the 80s were mostly related to oral and transdermal delivery, and were based on simple but effective mechanisms, such ... growth employment and redistribution pdfWebb4 okt. 2024 · Prodrug design for brain delivery of small- and medium-sized neuropeptides was reviewed, focusing on thyrotropin-releasing hormone and structurally related peptides as examples. We have summarized our most important advances in methodology, as well as assessed the benefits and limitations of bioreversible chemical manipulation … growth employment and redistribution strategyWebbApr 2013 - Aug 20152 years 5 months. Liverpool, United Kingdom. I was responsible for characterization of circulating strains potency, immunogenicity and antigenicity for selection of viral strains to produce the annual quadrivalent live attenuated flu vaccine. Additionally, I coordinated animal experiments related with research. filter in notion