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Trimethyllysine dioxygenase

WebMITOCHONDRIAL DIOXYGENASE* (Received for publication, October 21, 1977) JAMES D. HULSE,$ STEVEN R. ELLIS,$ AND LAVELL M. HENDERSON From the Department of Biochemistry, College of Biological Sciences, University of Minnesota, St. ... Trimethyllysine has been used as an effective precursor of carnitine in whole animal experiments (7, 8) … WebMar 14, 2012 · Carnitine is derived from dietary sources and synthesized endogenously from trimethyllysine (TML), which is released upon protein degradation. The released TML is further oxidized to γ-butyrobetaine (BB) by the action of trimethyllysine dioxygenase (TMLHE), 3-hydroxy-N-TML aldolase and 4-N-trimethylaminobutyraldehyde …

Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an ...

Web{"numberOfHits":1,"results":[{"id":"GO:0005506","isObsolete":false,"name":"iron ion binding","definition":{"text":"Binding to an iron (Fe) ion."},"synonyms":[{"name ... WebProtein target information for Trimethyllysine dioxygenase, mitochondrial (human). Find diseases associated with this biological target and compounds tested against it in … counties in spanish https://solrealest.com

Submitochondrial localization of 6‐N‐trimethyllysine …

WebOct 1, 2004 · The product of this reaction is 3-hydroxy- N6 -trimethyllysine and it appears to be the only step in which the enzyme is located in the mitochondria. 3-Hydroxy- N6 -trimethyllysine is converted to 4- N -trimethylammoniobutanal and glycine by 3-hydroxy- N6 -trimethyllysine aldolase. WebJan 14, 2011 · trimethyllysine dioxygenase Alternative Name(s) epsilon-trimethyllysine 2-oxoglutarate dioxygenase: TML-alpha-ketoglutarate dioxygenase: TMLD: TML dioxygenase: TML hydroxylase: trimethyllysine,2-oxoglutarate dioxygenase: trimethyllysine alpha-ketoglutarate dioxygenase: Reaction catalysed WebThe trimethyllysine dioxygenase enzyme catalyzes the first step in the carnitine biosynthesis pathway, which is part of amine biosynthesis. Carnitine is a molecule that … brentwood cathedral lunchtime concerts

TMLHE trimethyllysine hydroxylase, epsilon [ (Ma

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Trimethyllysine dioxygenase

Trimethylsilyl Derivative - an overview ScienceDirect Topics

WebGene ID: 105727255, updated on 3-Jul-2024. Summary Other designations. LOW QUALITY PROTEIN: trimethyllysine dioxygenase, mitochondrial WebDec 1, 2014 · N 6-trimethyllysine dioxygenase (TMLD) is the first enzyme in the carnitine/acylcarnitine biosynthesis pathway. Inactivation of the TMLHE gene (TMLHE …

Trimethyllysine dioxygenase

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WebApr 10, 2024 · The first step in carnitine biosynthesis is catalyzed by trimethyllysine hydroxylase (TMLH), a non-heme Fe (II) and 2-oxoglutarate (2OG)-dependent oxygenase, … WebJan 14, 2011 · trimethyllysine dioxygenase Synonyms ε -trimethyllysine 2-oxoglutarate dioxygenase oxygenase, trimethyllysine di- TML dioxygenase TML hydroxylase TML- α -ketoglutarate dioxygenase TMLD trimethyllysine α -ketoglutarate dioxygenase CAS registry number 84012-77-1 Keywords Molecular Weight Analytical Chemistry Reaction Type …

Webtrimethyllysine dioxygenase, mitochondrial, TML dioxygenase, TML hydroxylase, TML-alpha-ketoglutarate dioxygenase, butyrobetaine (gamma), 2-oxoglutarate dioxygenase 2 (gamma-butyrobetaine hydroxylase), epsilon-trimethyllysine 2-oxoglutarate dioxygenase. GeneRIFs: Gene References Into Functions. WebJan 14, 2011 · Trimethyllysine dioxygenase (EC 1.14.11.8) Cite Download Contents 1 Names and Identifiers 2 Pathways 3 Biochemical Reactions 4 Catalytic Activity 5 …

WebIn enzymology, a trimethyllysine dioxygenase is an enzyme that catalyzes the chemical reaction TMLH is a member of the alpha-ketoglutarate-dependent hydroxylases … WebNε,Nε,Nε-Trimethyllysine hydrochloride Empirical Formula (Hill Notation): C9H20N2O2 · HCl CAS No.: 55528-53-5 Molecular Weight: 224.73 Match Criteria: Product Name, Keyword All Photos ( 1) Anti-TMLHE antibody …

WebConverts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (PubMed:11431483, PubMed:23092983). This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded …

WebDec 1, 2014 · Trimethyllysine hydroxylase (TMLH) catalyses the first step in carnitine biosynthesis – the conversion of N6,N6,N6-trimethyl- l -lysine to 3-hydroxy-N6,N6,N6-trimethyl- l -lysine. By changing carnitine availability it is possible to optimise cardiac energy metabolism, that is beneficial under certain ischemic conditions. brentwood cathedral mass timesWebWhen trimethyllysine is released from cognate proteins via proteolysis, it serves as a precursor for carnitine biosynthesis. Mitochondrial 6-N-trimethyllysine dioxygenase converts 6-N-trimethyllysine to 3-hydroxy-6-N-trimethyllysine as the … counties in tennessee by populationcounties in tennessee ranked by populationWebSep 6, 2024 · Only trimethyllysine dioxygenase (TMLD) and γ-butyrobetaine dioxygenase (BBD) deficiencies have been reported; both are denoted with asterisks. ( b) Carnitine transport and mitochondrial carnitine–acylcarnitine cycle. brentwood cathedral live streamingIn enzymology, a trimethyllysine dioxygenase (TMLH; EC 1.14.11.8) is an enzyme that catalyzes the chemical reaction N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 TMLH is a member of the alpha-ketoglutarate-dependent hydroxylases superfamily. The 3 substra… brentwood cathedral parkingWebMar 13, 2024 · name: trimethyllysine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3 … counties in tennessee with citiesWebFeb 5, 1986 · The data indicate that the reduction in the level of NAD kinase activation is the direct result of trimethylation of lysine 115 of calmodulin, provide a precedent for a … counties in tennessee in eastern time zone